Epidermal growth factor is a potent inhibitor of renin secretion.
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Epidermal growth factor is a potent inhibitor of renin secretion.
Epidermal growth factor (EGF) is not only a cell mitogen but a potent vasoconstrictor that shares many properties with angiotensin II. Because EGF is localized in the kidney, we have studied the direct effects of EGF on renin secretion using both static incubations and perifusions of rat renal cortical slices. EGF at 5 x 10(-9) M significantly inhibited renin secretion in static incubations (co...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1993
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.21.5.654